In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …

The present article summarizes recent developments in the characterization of genetic
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …

There is wide evidence that CRC could be prevented by regular physical activity, keeping a
healthy body weight, and following a healthy and balanced diet. Many sporadic CRCs …

The development of genome-wide massively parallel sequencing, ie, whole-genome and
whole-exome sequencing, and copy number approaches has raised high expectations for …

Colorectal cancer (CRC) is among the five most commonly diagnosed cancers worldwide,
constituting 6% of all cancers and the third leading cause of cancer death. CRC is the third …

Colorectal cancer (CRC) is the third most common cancer diagnosed globally and is also
one of the leading causes of cancer deaths in both men and women. The progression of …

The introduction of next-generation sequencing (NGS) technology in testing for hereditary
cancer susceptibility allows testing of multiple cancer susceptibility genes simultaneously …

The current understanding of the inherited risk of colorectal cancer (CRC) started with an
observational clinical era in the late 19th century, which was followed by a genetic era …

Three-dimensional (3D) spheroid culture provides opportunities to model tumor growth
closer to its natural context. The collagen network in the extracellular matrix supports …