Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

pH-sensitive fluorescent proteins have revolutionized the field of cellular imaging and
physiology, offering insight into the dynamic pH changes that underlie fundamental cellular …

Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …

Bladder cells are constantly exposed to multiple xenobiotics and bioactive metabolites. In
addition to this challenging chemical environment, they are also exposed to shear stress …

Alzheimer's disease (AD) is associated with the accumulation and aggregation of amyloid in
the brain. The cation channel TRPV2 may mediate the pathological changes in mild …

While reactive oxygen species (ROS) have long been known to drive aging and
neurodegeneration, their persistent depletion below basal levels also disrupts organismal …

The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the
adhesion GPCR family. Mutations in VLGR1 have been associated with the human Usher …

Abstract Background and Objective Melatonin plays an important role in various beneficial
functions, including promoting differentiation. However, effects on osteogenic differentiation …

Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the
substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron …

Mitochondria require an extensive proteome to maintain a variety of metabolic reactions,
and changes in cellular demand depend on rapid adaptation of the mitochondrial protein …