Broadening horizons: the role of ferroptosis in cancer

X Chen, R Kang, G Kroemer, D Tang - Nature reviews Clinical oncology, 2021 - nature.com
The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …

[HTML][HTML] Molecular mechanisms of ferroptosis and their involvement in brain diseases

I Costa, DJ Barbosa, S Benfeito, V Silva… - Pharmacology & …, 2023 - Elsevier
Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Y Yu, Y Yan, F Niu, Y Wang, X Chen, G Su, Y Liu… - Cell death …, 2021 - nature.com
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …

Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Iron metabolism in ferroptosis

X Chen, C Yu, R Kang, D Tang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Y Su, B Zhao, L Zhou, Z Zhang, Y Shen, H Lv… - Cancer letters, 2020 - Elsevier
Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …

Targeting ferroptosis to iron out cancer

B Hassannia, P Vandenabeele, TV Berghe - Cancer cell, 2019 - cell.com
One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

Role of GPX4 in ferroptosis and its pharmacological implication

TM Seibt, B Proneth, M Conrad - Free Radical Biology and Medicine, 2019 - Elsevier
Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid
peroxidation and metabolic constraints. Dependence on NADPH/H+, polyunsaturated fatty …

Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death

AM Battaglia, R Chirillo, I Aversa, A Sacco, F Costanzo… - Cells, 2020 - mdpi.com
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …