Severe congenital neutropenias are a heterogeneous group of rare haematological
diseases characterized by impaired maturation of neutrophil granulocytes. Patients with …

Abstract G-CSF and GM-CSF are used widely to promote the production of granulocytes or
APCs. The US Food and Drug Administration approved G-CSF (filgrastim) for the treatment …

The inherited marrow failure syndromes are a diverse set of genetic disorders characterized
by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …

BACKGROUND Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM)
syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function …

Chemotherapy‐and radiotherapy‐induced oral mucositis represents a therapeutic challenge
frequently encountered in cancer patients. This side effect causes significant morbidity and …

Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell
population under homeostatic conditions. Upon infection and in cancer, blood neutrophil …

Normal male volunteers receiving single doses of 3.45 pgkg Filgrastim by 30-minute
intravenous infusion had a mean serum concentration of 20.8 ng/mL 5 minutes after the end …

Neutrophils are phagocytes whose principal function is to maintain anti-bacterial immunity.
Neutrophils ingest and kill invading bacteria, releasing cytotoxic, chemotactic and …

Neutropenia, defined as an absolute neutrophil count (ANC)< 1.5× 10 9/L, encompasses a
wide range of diagnoses, from normal variants to life-threatening acquired and congenital …