The inability to make broad, minimally biased measurements of a cell's proteome stands as
a major bottleneck for understanding how gene expression translates into cellular …

New technologies are permitting large-scale quantitative studies of signal-transduction
networks. Such data are hard to understand completely by inspection and intuition.'Data …

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells.
Here, we show that oncogenic KRAS (KRAS G12D) also regulates tumor cell signaling via …

Signal transduction pathways control cellular responses to stimuli, but it is unclear how
molecular information is processed as a network. We constructed a systems model of 7980 …

Mathematical models are an essential tool in systems biology, linking the behaviour of a
system to the interactions between its components. Parameters in empirical mathematical …

Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in
tumor progression for a variety of cancer types, how it dysregulates signaling networks …

Genotoxic stress in mammalian cells, including those caused by anti-cancer chemotherapy,
can induce temporary cell-cycle arrest, DNA damage-induced senescence (DDIS), or …

The dynamics of gene expression are fundamental to the coordination of cellular responses.
Measurement of temporal gene expression patterns is currently limited to destructive low …

Tumor necrosis factor (TNF) is a proinflammatory cytokine that induces conflicting pro-and
antiapoptotic signals whose relative strengths determine the extent of cell death. TNF …

Microenvironments of biological cells are dominated in vivo by macromolecular crowding
and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture …