Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …

Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor
prognosis, short median patient survival and a very limited response to therapies. GBM has …

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of
somatic glioma driving alterations and suboptimal disease classification. We defined the …

Despite a deeper molecular understanding, human glioblastoma remains one of the most
treatment refractory and fatal cancers. It is known that the presence of macrophages and …

Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

RAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …

Both solid tumours and leukaemias show considerable histological and functional
heterogeneity. It is widely accepted that genetic lesions have a major role in determining …

To understand the relationships between the non-GCIMP glioblastoma (GBM) subgroups,
we performed mathematical modeling to predict the temporal sequence of driver events …

One signal that is overactivated in a wide range of tumour types is the production of a
phospholipid, phosphatidylinositol (3, 4, 5) trisphosphate, by phosphatidylinositol 3-kinase …

Most current research on human brain tumors is focused on the molecular and cellular
analysis of the bulk tumor mass. However, there is overwhelming evidence in some …