The strength and integrity of our bones depends on maintaining a delicate balance between
bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result …

Remodeling changes in paradental tissues are considered essential in effecting orthodontic
tooth movement. The force-induced tissue strain produces local alterations in vascularity, as …

Src family kinases (SFKs) have a critical role in cell adhesion, invasion, proliferation,
survival, and angiogenesis during tumor development. SFKs comprise nine family members …

As the structures of more and more proteins and nucleic acids become available, molecular
docking is increasingly considered for lead discovery. Recent studies consider the hit-rate …

The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in
normal cells is non-or weakly oncogenic. These observations have raised doubts about the …

Protein tyrosine phosphatases (PTPs) are signaling enzymes that control a diverse array of
cellular processes. Malfunction of PTP activity is associated with a number of human …

The most common skeletal complication of breast cancer is osteolytic bone metastasis. Bone
metastases are present in 80% of patients with advanced disease and cause significant …

Protein phosphorylation provides molecular control of complex physiological events within
cells. In many cases, phosphorylation on specific amino acids directly controls the assembly …

The three-dimensional structure of the anti-apoptotic protein Bcl-xL complexed to a 25-
residue peptide from the death promoting region of Bad was determined using NMR …

G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of
G-protein signalling (RGS)-protein family has important roles in GPCR signal transduction …