Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

FRS Passos, HG Araújo-Filho, BS Monteiro… - Phytomedicine, 2022 - Elsevier
Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

Diosgenin: An ingress towards solving puzzle for diabetes treatment

P Arya, P Kumar - Journal of Food Biochemistry, 2022 - Wiley Online Library
The consumption and composition of food in daily life predict our health in long run. The
relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin …

[HTML][HTML] Comparison of in vitro and in vivo antioxidant activities of six flavonoids with similar structures

Y Zeng, J Song, M Zhang, H Wang, Y Zhang, H Suo - Antioxidants, 2020 - mdpi.com
The in vitro and in vivo antioxidant activities of six flavonoids with similar structures,
including epicatechin (EC), epigallocatechin (EGC), procyanidin B2 (P), quercetin (Q) …

[HTML][HTML] Diosgenin Inhibits ROS Generation by Modulating NOX4 and mitochondrial respiratory Chain and suppresses apoptosis in diabetic nephropathy

Y Zhong, L Wang, R Jin, J Liu, R Luo, Y Zhang, L Zhu… - Nutrients, 2023 - mdpi.com
Diosgenin (DIO) is a dietary steroid sapogenin possessing multiple biological functions,
such as the amelioration of diabetes. However, the remission effect of DIO on diabetic …

[HTML][HTML] Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation

M Yan, S Man, Y Liang, L Ma, L Guo, L Huang… - Pharmacological …, 2023 - Elsevier
Nonalcoholic steatohepatitis (NASH), as the aggressive form of nonalcoholic fatty liver
disease (NAFLD), rapidly becomes the leading cause of end-stage liver disease or liver …

[HTML][HTML] Inosine pretreatment attenuates LPS-induced lung injury through regulating the TLR4/MyD88/NF-κB signaling pathway in vivo

B Mao, W Guo, X Tang, Q Zhang, B Yang, J Zhao… - Nutrients, 2022 - mdpi.com
Inosine is a type of purine nucleoside, which is considered to a physiological energy source,
and exerts a widely range of anti-inflammatory efficacy. The TLR4/MyD88/NF-κB signaling …

Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria-related pathways

L Ma, J Zhang, X Wang, J Yang, L Guo, X Wang… - European Journal of …, 2021 - Elsevier
Diosgenin (DSG) has attracted attention recently as a potential anticancer therapeutic agent
due to its profound antitumor activity. To better utilize DSG as an antitumor compound, two …

Effects of Herbs and Derived Natural Products on Lipopolysaccharide‐Induced Toxicity: A Literature Review

M Kianmehr, M Behdadfard… - Oxidative Medicine …, 2023 - Wiley Online Library
Introduction. Oxidative stress (OS) during inflammation can increase inflammatory
responses and damage tissue. Lipopolysaccharide (LPS) can induce oxidative stress and …

Unravelling the anti-inflammatory mechanism of Allium cepa: an integration of network pharmacology and molecular docking approaches

V Omoboyede, OS Onile, BF Oyeyemi, RT Aruleba… - Molecular Diversity, 2024 - Springer
Allium cepa, commonly known as onion, is a widely consumed spice that possesses
numerous pharmacological properties. A. cepa bioactive components are often explored in …

Therapeutic potential of isorhamnetin following acetaminophen-induced hepatotoxicity through targeting NLRP3/NF-κB/Nrf2

AM Rousta, A Shahmohammadi, Z Mehrabi… - Drug …, 2022 - thieme-connect.com
Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver
failure (ALF) in some countries including the United States and with few available …