Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Macrophages in atherosclerosis regression

TJ Barrett - Arteriosclerosis, thrombosis, and vascular biology, 2020 - Am Heart Assoc
Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

Nanomedicines for cardiovascular disease

BR Smith, ER Edelman - Nature Cardiovascular Research, 2023 - nature.com
The leading cause of death in the world, cardiovascular disease (CVD), remains a
formidable condition for researchers, clinicians and patients alike. CVD comprises a broad …

Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

J Chen, X Zhang, R Millican, J Sherwood… - Advanced drug delivery …, 2021 - Elsevier
Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries,
leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is …

Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

High-density lipoprotein-mimicking nanodiscs for chemo-immunotherapy against glioblastoma multiforme

P Kadiyala, D Li, FM Nuñez, D Altshuler, R Doherty… - ACS …, 2019 - ACS Publications
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no
cure. Treatment effectiveness for GBM has been limited due to tumor heterogeneity, an …

Advanced nanomedicines for the treatment of inflammatory diseases

R Brusini, M Varna, P Couvreur - Advanced drug delivery reviews, 2020 - Elsevier
Inflammation, a common feature of many diseases, is an essential immune response that
enables survival and maintains tissue homeostasis. However, in some conditions, the …

Advances in HDL: much more than lipid transporters

S Ben-Aicha, L Badimon, G Vilahur - International Journal of Molecular …, 2020 - mdpi.com
High Density Lipoprotein (HDL) particles, beyond serving as lipid transporters and playing a
key role in reverse cholesterol transport, carry a highly variable number of proteins, micro …

Targeting Theranostics of Atherosclerosis by Dual‐Responsive Nanoplatform via Photoacoustic Imaging and Three‐In‐One Integrated Lipid Management

B Ma, Y Xiao, Q Lv, G Li, Y Wang, G Fu - Advanced Materials, 2023 - Wiley Online Library
Atherosclerosis, as a life‐threatening cardiovascular disease with chronic inflammation and
abnormal lipid enrichment, is often difficult to treat timely due to the lack of obvious …