Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …

Extensive desmoplasia and poor vasculature renders pancreatic tumors severely hypoxic,
contributing to their aggressiveness and therapy resistance. Here, we identify the …

The transcription factor c-Myb is vital for cell survival, proliferation, differentiation, and
apoptosis. We have previously reported that c-Myb knockdown exacerbates neomycin …

Abstract ENO1, also called 2-phospho-D-glycerate hydrolase in cellular glycolysis, is an
enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate and plays an important …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to low
therapeutic response rates and poor prognoses. Majority of patients present with symptoms …

Impaired diabetic wound healing is an important issue in diabetic complications.
Proliferation and migration of keratinocytes are major processes of skin wound repair after …

Late diagnosis, unreliable prognostic assessment, and poorly-guided therapeutic planning
result in dismal survival of ovarian cancer (OC) patients. Therefore, identifying novel …

The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival
when aberrantly activated/expressed, thus contributing to malignant transformation …

Abstract Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible
for symmetric dimethylation of arginine (SDMA), and plays predominantly roles in human …

Simple Summary Globally, breast cancer (BC) is the most frequently diagnosed cancer in
women. Rapid advances in omics technologies have enabled the identification of …