Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

Since the discovery of HIV as the cause for AIDS 30 years ago, major progress has been
made, including the discovery of drugs that now control the disease. Here, we review the …

HIV integrase (IN) catalyzes the insertion into the genome of the infected human cell of viral
DNA produced by the retrotranscription process. The discovery of raltegravir validated the …

The HIV-1 capsid is a shell that encapsulates viral RNA, and forms a conical structure by
assembling oligomers of capsid (CA) proteins. Since the CA proteins are highly conserved …

HIV-1 integrase (IN) is an enzyme which is indispensable for the stable infection of host cells
because it catalyzes the insertion of viral DNA into the genome and thus is an attractive …

Abstract Treatment of HIV has long faced the challenge of high mutation rates leading to
rapid development of resistance, with ongoing need to develop new methods to effectively …

HIV‐1 integrase (IN) is one of the key enzymes in the viral replication cycle. It mediates the
integration of viral cDNA into the host cell genome. IN activity requires interactions with …

The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral
RNA and is highly conserved among many strains of the virus. It forms a conical structure by …

Several small molecule CD4 mimics, which inhibit the interaction of gp120 with CD4, have
been developed. Original CD4 mimics such as NBD-556, which has an aromatic ring, an …