Endosomal sorting sorted – motors, adaptors and lessons from in vitro and cellular studies

GMI Redpath… - Journal of Cell …, 2023 - journals.biologists.com
Motor proteins are key players in exerting spatiotemporal control over the intracellular
location of membrane-bound compartments, including endosomes containing cargo. In this …

[HTML][HTML] Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells

NA Tirumala, GMI Redpath, SV Skerhut, P Dolai… - Journal of Cell …, 2024 - rupress.org
Cytoplasmic dynein 1 (dynein) is the primary minus end–directed motor protein in most
eukaryotic cells. Dynein remains in an inactive conformation until the formation of a tripartite …

[HTML][HTML] Cytoplasmic dynein motors in photoreceptors

TM Dahl, W Baehr - Molecular vision, 2021 - ncbi.nlm.nih.gov
Cytoplasmic dyneins (dynein-1 and dynein-2) transport cargo toward the minus end of
microtubules and thus, are termed the “retrograde” cellular motor. Dynein-1 cargo may …

On and off controls within dynein–dynactin on native cargoes

P Sanghavi, P Kumar, A Roy… - Proceedings of the …, 2021 - National Acad Sciences
The dynein–dynactin nanomachine transports cargoes along microtubules in cells. Why
dynactin interacts separately with the dynein motor and also with microtubules is hotly …

Chlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection

J Sherry, L Dolat, E McMahon, DL Swaney… - bioRxiv, 2022 - biorxiv.org
Chlamydia trachomatis is an obligate intracellular pathogen that replicates within a
specialized membrane-bound compartment, called the inclusion. Chlamydia species …

Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture

NA Tirumala, G Redpath, N Kapoor-Kaushik, N Ariotti… - Biophysical …, 2022 - cell.com
Cytoplasmic dynein 1 (dynein) is the primary minus end-directed motor protein in eukaryotic
cells. Dynein remains in an inactive conformation until the formation of a tripartite complex …

[HTML][HTML] 地塞米松对体外培养胎鼠大脑皮质神经元胞浆Dynein 重链和Dynactin 表达的影响

程琳, 谢紫云, 里健, 薄涛 - Chinese Journal of Contemporary …, 2021 - ncbi.nlm.nih.gov
地塞米松对体外培养胎鼠大脑皮质神经元胞浆Dynein重链和Dynactin表达的影响- PMC Back
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Effect of dexamethasone on the expression of Dynein heavy chain and Dynactin in the cytoplasm of fetal rat cerebral cortical neurons cultured in vitro

L Cheng, ZY Xie, J Li, T Bo - Zhongguo Dang dai er ke za zhi …, 2021 - europepmc.org
Objective To study the effect of dexamethasone (DEX) on the expression of Dynein heavy
chain (DHC) and Dynactin in the cytoplasm of fetal rat cerebral cortical neurons cultured in …

[PDF][PDF] Single-molecule imaging of cytoplasmic dynein reveals the mechanism of motor activation and cargo capture

NA Tirumala, V Ananthanarayanan - scholar.archive.org
Cytoplasmic dynein 1 (dynein) is the primary minus enddirected motor protein in most
eukaryotic cells (1). Dynein remains in an inactive conformation until the formation of a …