Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural
abnormalities or impaired excretory renal function suggestive of a loss of functional …

Nature is a great source of inspiration in solving extremely complex problems, and it is every
day more common to use its strategies for the development of new materials, methods, and …

Imaging intact human organs from the organ to the cellular scale in three dimensions is a
goal of biomedical imaging. To meet this challenge, we developed hierarchical phase …

Nephron number may be an important determinant of kidney health but has been difficult to
study in living humans. We evaluated 1638 living kidney donors at Mayo Clinic (MN and AZ …

The renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension and kidney
disease. The developing kidney can be programmed by various early-life insults by so …

Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in
management. CKD can begin in early life by so-called “developmental programming” or …

Hypertension and chronic kidney disease (CKD) have a significant impact on global
morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has …

The developmental origins of health and disease theory is based on evidence that a
suboptimal environment during fetal and neonatal development can significantly impact the …

Children born with a solitary functioning kidney (SFK) have an increased risk of
hypertension and kidney disease from early in adulthood. In response to a reduction in …

Children born at low birth weights (both due to prematurity and/or intrauterine growth
restriction) show increased risk of kidney dysfunction during adulthood. A better …