The introduction of fluorine atoms into molecules and materials across many fields of
academic and industrial research is now commonplace, owing to their unique properties. A …

The area of fluorinated amino acid synthesis has seen rapid growth over the past decade.
As reports of singly fluorinated natural amino acid derivatives have grown, researchers have …

Cycloadditions are known to be one of the most abundant, versatile and valuable classes of
chemical reactions. Among various efficient chemical processes, cycloaddition is an …

Stapled peptides are regarded as the promising next-generation therapeutics because of
their improved secondary structure, membrane permeability and metabolic stability as …

The efficacy of drugs and biomolecules relies on their ability to pass through the bilayer. The
development of methods to directly and sensitively monitor these membrane transport …

A visible light-induced diastereoselective synthesis of trifluoromethylated cyclobutane
derivatives is described, consisting of [2+ 2]-photocycloaddition and water-assisted …

Pyridylsulfone‐and fluoroalkylated group‐activated olefins underwent highly efficient
diastereo‐and enantioselective 1, 3‐dipolar cycloadditions across various aromatic and …

BP100 is a multifunctional membrane-active peptide of only 11 amino acids, with a high
antimicrobial activity, an efficient cell-penetrating ability, and low hemolytic side-effects. It …

A conformationally restricted monofluorinated α‐amino acid,(3‐fluorobicyclo [1.1. 1] pentyl)
glycine (F‐Bpg), was designed as a label for the structural analysis of membrane‐bound …

γ-(4S)-Trifluoromethyl proline was synthesised according to a modified literature protocol
with improved yield on a multigram scale. Conformational properties of the amide bond …