Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age‐Related Macular Degeneration

CK Mahendra, LTH Tan, P Pusparajah… - Oxidative Medicine …, 2020 - Wiley Online Library
Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they
not only mediate and control the transfer of fluids and solutes but also protect the retina …

METTL3 attenuates proliferative vitreoretinopathy and epithelial‐mesenchymal transition of retinal pigment epithelial cells via wnt/β‐catenin pathway

X Ma, C Long, F Wang, B Lou, M Yuan… - Journal of cellular …, 2021 - Wiley Online Library
Proliferative vitreoretinopathy (PVR) is a refractory vitreoretinal fibrosis disease, and
epithelial‐mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is the key …

m6A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway

H Zhang, P Zhang, C Long, X Ma… - Journal of cellular …, 2020 - Wiley Online Library
Retinoblastoma (RB) is a common intraocular malignancy in children. Due to the poor
prognosis of RB, it is crucial to search for efficient diagnostic and therapeutic strategies …

Oxidative stress‐induced lncRNA CYLD‐AS1 promotes RPE inflammation via Nrf2/miR‐134‐5p/NF‐κB signaling pathway

H Du, Z Huang, X Zhou, X Kuang, C Long… - The FASEB …, 2022 - Wiley Online Library
Oxidative stress‐induced damage to and dysfunction of retinal pigment epithelium (RPE)
cells are important pathogenetic factors of age‐related macular degeneration (AMD); …

Circular noncoding RNA NR3C1 acts as a miR-382-5p sponge to protect RPE functions via regulating PTEN/AKT/mTOR signaling pathway

X Chen, C Jiang, R Sun, D Yang, Q Liu - Molecular Therapy, 2020 - cell.com
Age-related macular degeneration (AMD) is a universal leading cause for irreversible
blindness in the elderly population. Dedifferentiation of retinal pigment epithelium (RPE) …

Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl

Y Markitantova, A Fokin, D Boguslavsky… - International Journal of …, 2023 - mdpi.com
The reprogramming of retinal pigment epithelium (RPE) cells into retinal cells
(transdifferentiation) lies in the bases of retinal regeneration in several Urodela. The …

miR‐132‐3p boosts caveolae‐mediated transcellular transport in glioma endothelial cells by targeting PTEN/PI3K/PKB/Src/Cav‐1 signaling pathway

Y Gu, R Cai, C Zhang, Y Xue, Y Pan, J Wang… - The FASEB …, 2019 - Wiley Online Library
Blood–brain tumor barrier (BTB) impedes the transportation of antitumor therapeutic drugs
into brain tumors. Its mechanism is still unknown, but learning how to improve the BTB …

Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway

H Tang, H Du, X Kuang, H Huang, J Zeng… - Frontiers in …, 2022 - frontiersin.org
Age-related macular degeneration (AMD), which is the leading cause of blindness among
the elderly in western societies, is majorly accompanied by retinal pigment epithelium (RPE) …

[HTML][HTML] Enhancing ocular protection against UVB: The role of irigenin in modulating oxidative stress and apoptotic pathways In Vivo

KL Yeh, SW Wu, CY Chiang, CJ Chen, WY Chen… - Biomedicine & …, 2024 - Elsevier
Oxidative damage contributes to age-related macular degeneration. Irigenin possesses
diverse pharmacologic properties, including antioxidative and antiapoptotic effects. Our in …

Silibinin Prevents TGFβ-Induced EMT of RPE in Proliferative Vitreoretinopathy by Inhibiting Stat3 and Smad3 Phosphorylation

X Ma, Y Xie, Y Gong, C Hu, K Qiu… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: The purpose of this study was to investigate the effects of silibinin on epithelial-
mesenchymal transition (EMT) of retinal pigment epithelial (RPE) and proliferative …