Consensus guidelines for the use and interpretation of angiogenesis assays

P Nowak-Sliwinska, K Alitalo, E Allen, A Anisimov… - Angiogenesis, 2018 - Springer
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Zebrafish as a successful animal model for screening toxicity of medicinal plants

A Modarresi Chahardehi, H Arsad, V Lim - Plants, 2020 - mdpi.com
The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro
experiments and developmental toxicity studies. Zebrafish may be used to determine the …

Genetic compensation triggered by mutant mRNA degradation

MA El-Brolosy, Z Kontarakis, A Rossi, C Kuenne… - Nature, 2019 - nature.com
Genetic robustness, or the ability of an organism to maintain fitness in the presence of
harmful mutations, can be achieved via protein feedback loops. Previous work has …

m6A modulates haematopoietic stem and progenitor cell specification

C Zhang, Y Chen, B Sun, LU Wang, Y Yang, D Ma, J Lv… - Nature, 2017 - nature.com
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant modification
on eukaryote messenger RNA (mRNA). Although the rapid development of high-throughput …

Assessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerio

A Babayigit, D Duy Thanh, A Ethirajan, J Manca… - Scientific reports, 2016 - nature.com
Intensive development of organometal halide perovskite solar cells has lead to a dramatic
surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite …

Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish

FO Kok, M Shin, CW Ni, A Gupta, AS Grosse… - Developmental cell, 2015 - cell.com
The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

Role of PFKFB3-driven glycolysis in vessel sprouting

K De Bock, M Georgiadou, S Schoors, A Kuchnio… - Cell, 2013 - cell.com
Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …

Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts

R Fior, V Póvoa, RV Mendes… - Proceedings of the …, 2017 - National Acad Sciences
Cancer is as unique as the person fighting it. With the exception of a few biomarker-driven
therapies, patients go through rounds of trial-and-error approaches to find the best …

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

DB Gurevich, CE Severn, C Twomey… - The EMBO …, 2018 - embopress.org
Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies
of healing. Here, we investigate the cellular interactions between innate immune cells and …

In vivo genome editing using a high-efficiency TALEN system

VM Bedell, Y Wang, JM Campbell, TL Poshusta… - Nature, 2012 - nature.com
The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and
human disease with a rich array of in vivo genetic and molecular tools. However, the inability …