Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Zebrafish as a successful animal model for screening toxicity of medicinal plants
The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro
experiments and developmental toxicity studies. Zebrafish may be used to determine the …
experiments and developmental toxicity studies. Zebrafish may be used to determine the …
Genetic compensation triggered by mutant mRNA degradation
Genetic robustness, or the ability of an organism to maintain fitness in the presence of
harmful mutations, can be achieved via protein feedback loops. Previous work has …
harmful mutations, can be achieved via protein feedback loops. Previous work has …
m6A modulates haematopoietic stem and progenitor cell specification
C Zhang, Y Chen, B Sun, LU Wang, Y Yang, D Ma, J Lv… - Nature, 2017 - nature.com
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant modification
on eukaryote messenger RNA (mRNA). Although the rapid development of high-throughput …
on eukaryote messenger RNA (mRNA). Although the rapid development of high-throughput …
Assessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerio
Intensive development of organometal halide perovskite solar cells has lead to a dramatic
surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite …
surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite …
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish
The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …
Role of PFKFB3-driven glycolysis in vessel sprouting
K De Bock, M Georgiadou, S Schoors, A Kuchnio… - Cell, 2013 - cell.com
Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …
Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts
Cancer is as unique as the person fighting it. With the exception of a few biomarker-driven
therapies, patients go through rounds of trial-and-error approaches to find the best …
therapies, patients go through rounds of trial-and-error approaches to find the best …
Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression
DB Gurevich, CE Severn, C Twomey… - The EMBO …, 2018 - embopress.org
Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies
of healing. Here, we investigate the cellular interactions between innate immune cells and …
of healing. Here, we investigate the cellular interactions between innate immune cells and …
In vivo genome editing using a high-efficiency TALEN system
VM Bedell, Y Wang, JM Campbell, TL Poshusta… - Nature, 2012 - nature.com
The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and
human disease with a rich array of in vivo genetic and molecular tools. However, the inability …
human disease with a rich array of in vivo genetic and molecular tools. However, the inability …