[HTML][HTML] Image-based profiling for drug discovery: due for a machine-learning upgrade?
SN Chandrasekaran, H Ceulemans, JD Boyd… - Nature Reviews Drug …, 2021 - nature.com
Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …
biological images is reduced to a multidimensional profile, a collection of extracted image …
Optimizing the Cell Painting assay for image-based profiling
BA Cimini, SN Chandrasekaran, M Kost-Alimova… - Nature protocols, 2023 - nature.com
In image-based profiling, software extracts thousands of morphological features of cells from
multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used …
multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used …
[HTML][HTML] A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck… - Cell, 2017 - cell.com
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs,
and disease states are connected by virtue of common gene-expression signatures. Here …
and disease states are connected by virtue of common gene-expression signatures. Here …
[HTML][HTML] Opportunities and challenges in phenotypic drug discovery: an industry perspective
Phenotypic drug discovery (PDD) approaches do not rely on knowledge of the identity of a
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …
specific drug target or a hypothesis about its role in disease, in contrast to the target-based …
Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes
In morphological profiling, quantitative data are extracted from microscopy images of cells to
identify biologically relevant similarities and differences among samples based on these …
identify biologically relevant similarities and differences among samples based on these …
High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
Harnessing connectivity in a large-scale small-molecule sensitivity dataset
B Seashore-Ludlow, MG Rees, JH Cheah, M Cokol… - Cancer discovery, 2015 - AACR
Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic
agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) …
agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) …
[HTML][HTML] Learning representations for image-based profiling of perturbations
Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient
and powerful way of studying cell biology, and requires computational methods for …
and powerful way of studying cell biology, and requires computational methods for …
[HTML][HTML] Mass cytometry imaging for the study of human diseases—applications and data analysis strategies
H Baharlou, NP Canete, AL Cunningham… - Frontiers in …, 2019 - frontiersin.org
High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …
[HTML][HTML] Image Data Resource: a bioimage data integration and publication platform
E Williams, J Moore, SW Li, G Rustici, A Tarkowska… - Nature …, 2017 - nature.com
Access to primary research data is vital for the advancement of science. To extend the data
types supported by community repositories, we built a prototype Image Data Resource …
types supported by community repositories, we built a prototype Image Data Resource …