Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

This study aimed to investigate the antidiabetic activity of water–ethanol extract of green
macroalgae Enteromorpha prolifera (EPW) and its flavonoid‐rich fraction less than 3 kDa …

Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated
in energy balance and glucose metabolism control. However, the precise mechanisms …

The prevalence of obesity in children and adolescents is increasing, and it is recognised as
a complex disorder that often begins in early childhood and persists throughout life. Both …

The central melanocortin system plays a fundamental role in the control of feeding and body
weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus …

Context Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt
signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia …

Objective Obesity is one of the primary healthcare challenges of the 21st century. Signals
relaying information regarding energy needs are integrated within the brain to influence …

Evidence for involvement of the central nervous system (CNS) in the regulation of glucose
metabolism dates back to the 19th century, although the majority of the research on glucose …

Aims/hypothesis The brain is a major consumer of glucose as an energy source and
regulates systemic glucose as well as energy balance. Although glucose transporters such …

Aims/hypothesis Renal GLUT2 is increased in diabetes, thereby enhancing glucose
reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 …