Relative telomere length change in colorectal carcinoma and its association with tumor characteristics, gene expression and microsatellite instability

MG Kibriya, M Raza, M Kamal, Z Haq, R Paul… - Cancers, 2022 - mdpi.com
Simple Summary Telomeres are specialized repeat DNA sequences at the ends of each
chromosome. The primary function of telomeres is to prevent genomic instability. Telomeres …

A transcriptome and methylome study comparing tissues of early and late onset colorectal carcinoma

MG Kibriya, M Raza, A Quinn, M Kamal… - International Journal of …, 2022 - mdpi.com
There is an increase in the incidence of early onset colorectal carcinoma (EOCRC). To
better understand if there is any difference in molecular pathogenesis of EOCRC and late …

[HTML][HTML] Microsatellite Status Detection of Colorectal Cancer: Evaluation of Inconsistency between PCR and IHC

J Chen, Q Yan, J Sun, Q Wang, Y Tao, D Xiao… - Journal of …, 2023 - ncbi.nlm.nih.gov
Objective: An essential component of precision medical treatment for colorectal cancer
(CRC) is the use of microsatellite state in combination with polymerase chain reaction (PCR) …

High performance methylated DNA markers for detection of colon adenocarcinoma

RAM Klein Kranenbarg, AH Vali, JNM IJzermans… - Clinical …, 2021 - Springer
Background Colon cancer (CC) is treatable if detected in its early stages. Improved CC
detection assays that are highly sensitive, specific, and available at point of care are …

Development and validation of a new stage-specific nomogram model for predicting cancer-specific survival in patients in different stages of colon cancer: a SEER …

C Hu, F Shi, Z Zhang, L Zhang, R Liu, X Sun… - Frontiers in …, 2022 - frontiersin.org
Background The effects of laterality of the primary tumor on survival in patients in different
stages of colon cancer are contradictory. We still lack a strictly evaluated and validated …

A pan-cancer analysis of the core pre-mRNA 3′ end processing factors, and their association with prognosis, tumor microenvironment, and potential targets

X Li, Y Che, X Wang, Y Zhu - Scientific Reports, 2024 - nature.com
Alternative polyadenylation (APA) is a crucial mechanism for regulating gene expression
during pre-mRNA 3′ processing. Pre-mRNA 3′ end processing factors is the main factor …

[HTML][HTML] Association of KRAS Mutation and Gene Pathways in Colorectal Carcinoma: A Transcriptome- and Methylome-Wide Study and Potential Implications for …

F Jasmine, A Almazan, Y Khamkevych… - International Journal of …, 2024 - mdpi.com
Kirsten Rat Sarcoma (KRAS) is the most commonly mutated oncogene in colorectal
carcinoma (CRC). We have previously reported the interactions between microsatellite …

LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis

Y Wang, H Gong, Y Cao - Hereditas, 2023 - Springer
Abstract Background WAC-antisense RNA1 (WAC-AS1) is a newly identified long non-
coding RNA (lncRNA) implicated in the prognosis and development of a few types of tumors …

Pathways Related to Colon Inflammation Are Associated with Colorectal Carcinoma: A Transcriptome-and Methylome-Wide Study

MG Kibriya, F Jasmine, J Pekow, A Munoz, C Weber… - Cancers, 2023 - mdpi.com
Simple Summary Colon cancer is one of the common cancers affecting a large number of
patients globally. In sporadic CRC, several genetic factors may play important roles such as …

Association of Microsatellite Instability and Gene Expression Profile in Colorectal Carcinoma and Potential Implications for Therapy

MG Kibriya, F Jasmine, Y Khamkevych, M Raza… - Medicina, 2024 - mdpi.com
Background and Objective: In sporadic colorectal carcinomas (CRC), microsatellite
instability (MSI) pathways play important roles. Previously, we showed differences in DNA …