Any opinions, findings, and conclusions or recommendations expressed in this material are
those of the authors and do not necessarily reflect the views of the US Army Contracting …

Abstract The latest French Guidelines for the management in the first 24 hours of patients
with severe traumatic brain injury (TBI) were published in 1998. Due to recent changes …

Objectives: To produce a treatment algorithm for the ICU management of infants, children,
and adolescents with severe traumatic brain injury. Data Sources: Studies included in the …

Background Hypothermia therapy improves survival and the neurologic outcome in animal
models of traumatic brain injury. However, the effect of hypothermia therapy on the …

Effective management of intracranial hypertension involves meticulous avoidance of factors
that precipitate or aggravate increased intracranial pressure. When intracranial pressure …

This Clinical Report was retired October 2023. OBJECTIVE: To review and revise the 1987
pediatric brain death guidelines. METHODS: Relevant literature was reviewed …

Object Brain edema resulting from traumatic brain injury (TBI) or ischemia if uncontrolled
exhausts volume reserve and leads to raised intracranial pressure and brain herniation. The …

Background On the basis of mixed results from previous trials, we assessed whether
therapeutic hypothermia for 48–72 h with slow rewarming improved mortality in children …

Traumatic axonal injury (TAI) is thought to be a major contributor to cognitive dysfunction
following traumatic brain injury (TBI), however TAI is difficult to diagnose or characterize non …

Moderate-to-severe traumatic brain injury (TBI) remains a major global challenge, with rising
incidence, unchanging mortality and lifelong impairments. State-of-the-science reviews are …