A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …

Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

Over the last decade, researchers have discovered that a group of apparently unrelated
neurodegenerative disorders, such as Parkinson's disease, have remarkable cellular and …

Pleiotropic mechanisms have been implicated in Alzheimer's disease (AD), including
transcriptional dysregulation, protein misprocessing and synaptic dysfunction, but how they …

Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …

Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts;
however, how genes involved in cholesterol biosynthesis are regulated in lens cells remains …

The proteasome system is a large and complex molecular machinery responsible for the
degradation of misfolded, damaged, and redundant cellular proteins. When proteasome …

The failure of the proper protein turnover in the nervous system is mainly linked to a variety
of neurodegenerative disorders. Therefore, a better understanding of key protein …

Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative and neuromuscular
genetic disease caused by the expansion of a polyglutamine-encoding CAG tract in the …

Misfolded proteins are the main common feature of neurodegenerative diseases, thereby,
normal proteostasis is an important mechanism to regulate the neural survival and the …