[HTML][HTML] Benzimidazole and its derivatives: Recent Advances (2020–2022)

O Ebenezer, F Oyetunde-Joshua, OD Omotoso… - Results in …, 2023 - Elsevier
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

B Suliphuldevara Mathada… - …, 2023 - Wiley Online Library
Heterocycles are a privileged motif that appears as a momentous objective in medicinal
chemistry. An important class of compounds for drug discovery and design is indole and its …

Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya

WR Mir, BA Bhat, MA Rather, S Muzamil… - Scientific reports, 2022 - nature.com
Geranium wallichianum D. Don ex Sweet is a well-known medicinal plant in Kashmir
Himalya. The evidence for its modern medicinal applications remains majorly unexplored …

Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021)

LS Feng, WQ Su, JB Cheng, T Xiao, HZ Li… - Archiv der …, 2022 - Wiley Online Library
Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

Recent advances in the anticancer applications of benzimidazole derivatives

M Mavvaji, S Akkoc - ChemistrySelect, 2023 - Wiley Online Library
Cancer, one of the most deadly diseases worldwide, is still a crucial challenge to human
well‐being. Hence, the design and development of modern protocols to cure diverse kinds …

Synthesis, Anticancer Activity, and In Silico Modeling of Alkylsulfonyl Benzimidazole Derivatives: Unveiling Potent Bcl-2 Inhibitors for Breast Cancer

Y Abbade, MM Kisla, MAK Hassan, I Celik… - ACS …, 2024 - ACS Publications
A series of alkylsulfonyl 1 H-benzo [d] imidazole derivatives were synthesized and evaluated
for anticancer activity against human breast cancer cells, MCF-7 in vitro. The cytotoxic …

A new approach for the synthesis of bis (3-Indolyl) pyridines via a cooperative vinylogous anomeric based oxidation using ammonium acetate as a dual reagent …

H Sepehrmansourie, M Zarei… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we introduced a new method for the synthesis of bis (3-indolyl) pyridines.
Accordingly, ammonium acetate was introduced as a dual reagent-catalyst role, for …

A Concise Review on Recent Development of Indole Derivatives for Anticancer Activities

BT Sridhar, NG Yernale, RS Gani, N Gupta… - Journal of the Indian …, 2024 - Elsevier
Indole heterocycles have been considered as noteworthy associated hybrids because of
their diverse applications in organic synthesis, and coordination chemistry, as well as in the …

Synthesis, DFT Molecular Geometry and Anticancer Activity of Symmetrical 2,2′-(2-Oxo-1H-benzo[d]imidazole-1,3(2H)-diyl) Diacetate and Its …

M Dhahri, FA Khan, AH Emwas, RB Alnoman… - Materials, 2022 - mdpi.com
To identify new candidate anticancer compounds, we here report the synthesis of
benzimidazole derivatives: diethyl 2, 2′-(2-oxo-1 H-benzo [d] imidazole-1, 3 (2 H)-diyl) …

A Comprehensive Review on the Benzimidazole Scaffold as a Potential Nucleus for Anticancer Activity

S Pathak, R Sharma - Letters in Organic Chemistry, 2023 - ingentaconnect.com
It is common knowledge that cancer is the world's biggest cause of mortality. This has led to
the ongoing introduction and validation of new cancer therapy outcomes. Benzimidazole …