End-to-end design of wearable sensors

HC Ates, PQ Nguyen, L Gonzalez-Macia… - Nature Reviews …, 2022 - nature.com
Wearable devices provide an alternative pathway to clinical diagnostics by exploiting
various physical, chemical and biological sensors to mine physiological (biophysical and/or …

Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

M Friedel, IAP Thompson, G Kasting, R Polsky… - Nature Biomedical …, 2023 - nature.com
The volume of interstitial fluid (ISF) in the human body is three times that of blood. Yet,
collecting diagnostically useful ISF is more challenging than collecting blood because the …

A wireless patch for the monitoring of C-reactive protein in sweat

J Tu, J Min, Y Song, C Xu, J Li, J Moore… - Nature biomedical …, 2023 - nature.com
The quantification of protein biomarkers in blood at picomolar-level sensitivity requires
labour-intensive incubation and washing steps. Sensing proteins in sweat, which would …

Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows

S Lin, X Cheng, J Zhu, B Wang, D Jelinek, Y Zhao… - Science …, 2022 - science.org
Therapeutic drug monitoring is essential for dosing pharmaceuticals with narrow therapeutic
windows. Nevertheless, standard methods are imprecise and involve invasive/resource …

Wearable electrochemical sensors for the monitoring and screening of drugs

H Teymourian, M Parrilla, JR Sempionatto… - ACS …, 2020 - ACS Publications
Wearable electrochemical sensors capable of noninvasive monitoring of chemical markers
represent a rapidly emerging digital-health technology. Recent advances toward wearable …

Wearable devices for the detection of COVID-19

HC Ates, AK Yetisen, F Güder, C Dincer - Nature Electronics, 2021 - nature.com
Wearable devices for the detection of COVID-19 | Nature Electronics Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial

TMJ Ewoldt, A Abdulla, WJR Rietdijk, AE Muller… - Intensive Care …, 2022 - Springer
Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

An antibody-based molecular switch for continuous small-molecule biosensing

IAP Thompson, J Saunders, L Zheng, AA Hariri… - Science …, 2023 - science.org
We present a generalizable approach for designing biosensors that can continuously detect
small-molecule biomarkers in real time and without sample preparation. This is achieved by …

Flexible hybrid sensor systems with feedback functions

K Xu, Y Lu, K Takei - Advanced Functional Materials, 2021 - Wiley Online Library
Skin‐like wearable sensors are regarded as key technologies toward home‐based
healthcare, human–machine interfaces, robotics, prostheses, and enhanced …

Optimizing antimicrobial use: challenges, advances and opportunities

TM Rawson, RC Wilson, D O'Hare, P Herrero… - Nature Reviews …, 2021 - nature.com
An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …