Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy

Y Zhou, Q Li, Y Wu, X Li, Y Zhou, Z Wang, H Liang… - ACS …, 2023 - ACS Publications
Self-assembly has emerged as an extensively used method for constructing biomaterials
with sizes ranging from nanometers to micrometers. Peptides have been extensively …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Single-dose injectable nanovaccine-in-hydrogel for robust immunotherapy of large tumors with abscopal effect

F Cheng, T Su, S Zhou, X Liu, S Yang, S Lin, W Guo… - Science …, 2023 - science.org
Current cancer immunotherapy [eg, immune checkpoint blockade (ICB)] only benefits small
subsets of patients, largely due to immunosuppressive tumor microenvironment (TME). In …

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Y Zhang, J Chen, L Shi, F Ma - Materials Horizons, 2023 - pubs.rsc.org
Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses,
have been envisioned as one of the most powerful tools for effective cancer immunotherapy …

Immunotherapeutic Hydrogel with Photothermal Induced Immunogenic Cell Death and STING Activation for Post‐Surgical Treatment

M Wang, X Zhang, B Liu, C Liu, C Song… - Advanced Functional …, 2023 - Wiley Online Library
Post‐surgical tumor recurrence remains a major clinical concern for patients with malignant
solid tumors. Herein, an immunotherapeutic hydrogel (SAPBA/ZMC/ICG) is developed by …

Stimuli-responsive polymeric nanovaccines toward next-generation immunotherapy

L Mao, P Ma, X Luo, H Cheng, Z Wang, E Ye, XJ Loh… - ACS …, 2023 - ACS Publications
The development of nanovaccines that employ polymeric delivery carriers has garnered
substantial interest in therapeutic treatment of cancer and a variety of infectious diseases …

Immunotherapy: cancer immunotherapy and its combination with nanomaterials and other therapies

Y Guo, F Gao, A Ahmed, M Rafiq, B Yu… - Journal of Materials …, 2023 - pubs.rsc.org
Immunotherapy is a new type of tumor treatment after surgery, radiotherapy and
chemotherapy, which can be used to manage and destroy tumor cells through activating or …

Engineering and delivery of cGAS-STING immunomodulators for the immunotherapy of cancer and autoimmune diseases

S Zhou, F Cheng, Y Zhang, T Su… - Accounts of chemical …, 2023 - ACS Publications
Conspectus The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING)
pathway is an emerging therapeutic target for the prophylaxis and therapy of a variety of …

[HTML][HTML] Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy

T Su, X Liu, S Lin, F Cheng, G Zhu - Bioactive Materials, 2023 - Elsevier
Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines.
Here, we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and …

[HTML][HTML] Overcoming challenges in the delivery of STING agonists for cancer immunotherapy: a comprehensive review of strategies and future perspectives

C Huang, N Shao, Y Huang, J Chen, D Wang, G Hu… - Materials Today Bio, 2023 - Elsevier
Abstract STING (Stimulator of Interferon Genes) agonists have emerged as promising agents
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …