IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis
Z Zhong, G Su, A Kijlstra, P Yang - Progress in retinal and eye research, 2021 - Elsevier
Uveitis is a group of diseases characterized by intraocular inflammation, of which some are
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …
Interleukin 15: biology and relevance to human disease
TA Fehniger, MA Caligiuri - Blood, The Journal of the American …, 2001 - ashpublications.org
Since the cloning of interleukin (IL)-15 six years ago, there have been numerous studies
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
TA Waldmann, Y Tagaya - Annual review of immunology, 1999 - annualreviews.org
▪ Abstract Interleukin-15 (IL-15) is a 14-to 15-kDa member of the 4 α-helix bundle family of
cytokines. IL-15 expression is controlled at the levels of transcription, translation, and …
cytokines. IL-15 expression is controlled at the levels of transcription, translation, and …
Sarcoidosis is a Th1/Th17 multisystem disorder
M Facco, A Cabrelle, A Teramo, V Olivieri, M Gnoato… - Thorax, 2011 - thorax.bmj.com
Background and aims Sarcoidosis is characterised by a compartmentalisation of CD4+ T
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …
Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
S Hofmann, A Franke, A Fischer, G Jacobs… - Nature …, 2008 - nature.com
Sarcoidosis is a complex chronic inflammatory disorder with predominant manifestation in
the lung. In the first genome-wide association study (> 440,000 SNPs) of this disease …
the lung. In the first genome-wide association study (> 440,000 SNPs) of this disease …
Sarcoidosis—scientific progress and clinical challenges
ES Chen, DR Moller - Nature Reviews Rheumatology, 2011 - nature.com
Sarcoidosis is an uncommon systemic inflammatory disorder characterized by noncaseating
granulomatous inflammation that most commonly affects the lungs, intrathoracic lymph …
granulomatous inflammation that most commonly affects the lungs, intrathoracic lymph …
Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease
A Di Sabatino, R Ciccocioppo, F Cupelli, B Cinque… - Gut, 2006 - gut.bmj.com
Background and aims: Epithelium derived interleukin (IL)-15 signalling via IL-15Rα is critical
for the development, activation, and survival of intraepithelial lymphocytes (IEL). We aimed …
for the development, activation, and survival of intraepithelial lymphocytes (IEL). We aimed …
Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ–upregulated interleukin-15
T Musso, L Calosso, M Zucca… - Blood, The Journal …, 1999 - ashpublications.org
Interleukin-15 (IL-15) is a potent regulator of T-, B-, and natural killer cell proliferation and
displays unusually tight controls of secretion. Even though IL-15 mRNA is constitutively …
displays unusually tight controls of secretion. Even though IL-15 mRNA is constitutively …
Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology
IL-15 has recently been detected in the synovium of patients with rheumatoid arthritis. IL-15-
activated T cells induce significant TNF-α synthesis by macrophages via a cell contact …
activated T cells induce significant TNF-α synthesis by macrophages via a cell contact …