Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …

Chemokine receptors comprise a large family of seven transmembrane domain G protein-
coupled receptors differentially expressed in diverse cell types. Biological activities have …

A selective advantage against infectious disease associated with increased heterozygosity
at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

Chronic viral infections can appear in two very different forms: those that are typically
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …

Chemokines and their receptors are involved in the pathogenesis of diseases ranging from
asthma to AIDS. Chemokine receptors are G-protein-coupled serpentine receptors that …

To understand the high variability of the asymptomatic interval between primary human
immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied …

CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains,
respectively, and a threshold number of CD4 and chemokine receptor molecules is required …