Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal
survival in cerebral ischemia. Previous studies found deficient mitophagy in ischemic …

The ubiquitin‐proteasome pathway and autophagy‐lysosome pathway are two major routes
for clearance of aberrant cellular components to maintain protein homeostasis and normal …

Cellular sumoylation processes are proposed targets for anti-viral and anti-cancer therapies.
We reported that Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) dysregulates …

Background/Aims: Transient receptor potential cation channel 1 (TRPC1)-mediated the
calcium (Ca 2+) influx plays an important role in several brain disorders. However, the …

Purpose Ixazomib is a selective, effective, and reversible inhibitor of 20S proteasome and is
approved for the treatment of multiple myeloma. Ubiquitin-conjugating enzyme E2 (UBE2K) …

Serotonin 1A receptors (5-HT1ARs) are implicated in the control of mood, cognition, and
memory and in various neuropsychiatric disorders such as depression and anxiety. As such …

Regulation of cell cycle arrest and re-entry triggered by DNA damage is vital for cell division
and growth and is also involved in cell survival. UV radiation can generate lesions in the …

Cerebral ischemia-reperfusion induces mitochondrial fragmentation and dysfunction, which
plays a critical role in the subsequent neuronal death and neurological impairment …

Neuron damage contributes to ischemic brain injury. Although FMS-like tyrosine kinase-3
(FLT3) plays a critical role in neuron survival, its function and molecular mechanism in …

Marine mammals are exposed to the oxidative stress induced by hypoxia/reoxygenation
cycles yet resist cellular damage. The availability of high-quality genomes promises to …