Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and
systemic inflammation where the close interaction between immune cells and soluble …

Epidemiological findings suggest a potential role for anti-citrullinated protein antibodies
(ACPAs) in rheumatoid arthritis (RA) pathogenesis. ACPA-positive RA is associated with …

Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …

Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue,
but the precise pathways of B cell activation and selection are not well understood. Here, we …

Genetic, environmental, and epigenetic factors simultaneously or serially contribute to
immune cells and resident joint tissue cell abnormalities, invariably leading to joint …

Adaptive immune cell function is regulated by a highly diverse receptor recombined from
variable germline-encoded segments that can recognize an almost unlimited array of …

We describe the study of a novel aptamer-based candidate for treatment of seropositive
rheumatoid arthritis. The candidate is a nanoparticle-formulated cyclic citrullinated peptide …

Rheumatoid arthritis (RA) is a common autoimmune rheumatic disease that causes chronic
synovitis, bone erosion, and joint destruction. The autoantigens in RA include a wide array …

Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it
is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B …

Background In rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-
antigens leads to the chronic inflammation of the synovium. Here, we perform an in-depth …