Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities
in epilepsy are very common and are often more problematic to individuals than the seizures …

The developing brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …

Ammonia is a ubiquitous waste product of protein metabolism that can accumulate in
numerous metabolic disorders, causing neurological dysfunction ranging from cognitive …

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …

Understanding neural network behavior is essential to shed light on epileptogenesis and
seizure propagation. The interconnectivity and plasticity of mammalian limbic and …