Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Small RNAs of 20–30 nucleotides can target both chromatin and transcripts, and thereby
keep both the genome and the transcriptome under extensive surveillance. Recent progress …

MicroRNAs (miRNAs) are initially expressed as long transcripts that are processed in the
nucleus to yield∼ 65-nucleotide (nt) RNA hairpin intermediates, termed pre-miRNAs, that …

MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are
processed from larger transcripts by sequential action of nuclear and cytoplasmic …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

The recent discovery of microRNAs (miRNAs) took many by surprise because of their
unorthodox features and widespread functions. These tiny,∼ 22-nucleotide, RNAs control …

microRNAs (miRNAs) are widespread among eukaryotes, and studies in several systems
have revealed that miRNAs can regulate expression of specific genes. Primary miRNA …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

Studies of nonsense-mediated mRNA decay in mammalian cells have proffered unforeseen
insights into changes in mRNA–protein interactions throughout the lifetime of an mRNA …