Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

Chalcone hybrids and their antimalarial activity

P Cheng, L Yang, X Huang, X Wang… - Archiv der …, 2020 - Wiley Online Library
Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus
Plasmodium, places a huge burden on global healthcare systems. A major challenge in the …

Molecular structure spectroscopic Elucidation, IEFPCM solvation (UV–Vis, MEP, FMO, NBO, NLO), molecular docking and biological assessment studies of lepidine (4 …

A Saral, P Sudha, S Muthu, S Sevvanthi… - Journal of Molecular …, 2022 - Elsevier
Quinoline compounds have attracted the curiosity of chemists due to their fascinating
biological potential. In the present study, the molecule 4-methylquinoline or lepidine is …

Synthesis and Biologically Activity of Novel 2-Chloro-3-Formyl-1, 5-Naphthyridine Chalcone Derivatives.

AI Ayoob, GT Sadeek, MY Saleh - Journal of Chemical …, 2022 - search.ebscohost.com
A new and efficient procedure has been described for the synthesis of 2-chloro-1, 5-
Naphthyridine-3-carbaldehyde (1) from the condensation of N-(pyridine-3-yl) acetamide in …

Identification of quinoline-chalcones and heterocyclic chalcone-appended quinolines as broad-spectrum pharmacological agents

D Atukuri, S Vijayalaxmi, R Sanjeevamurthy, L Vidya… - Bioorganic …, 2020 - Elsevier
Quinoline derivatives have been reported to possess enticing pharmacological properties. In
particular, quinoline-chalcones are identified as promising scaffolds for drug discovery. For a …

A comprehensive review on synthetic approach for antimalarial agents

A Kumar, D Paliwal, D Saini, A Thakur… - European journal of …, 2014 - Elsevier
Malaria has emerged as a major health problem worldwide after the appearance of resistant
strains of Plasmodium falciparum to the most of antimalarial drugs. The development of …

Spectroscopic profiling, DFT computations, molecular docking and molecular dynamic simulation of biologically active 5-isoquinolinesulfonic acid

A Saral, P Sudha, S Muthu, A Irfan - Journal of Biomolecular …, 2023 - Taylor & Francis
The title compound 5-isoquinolinesulfonic acid (5IQSA) is characterized using the FT-IR, FT-
Raman, NMR and UV-Vis spectra. The optimized molecular geometry, vibrational …

In vitro antileishmanial efficacy of antiplasmodial active aminoquinoline-chalcone hybrids

J Aucamp, DD N'Da - Experimental parasitology, 2022 - Elsevier
Significant overlaps in the geographical distribution of malaria and leishmaniasis increase
the risk for comorbidity, which can affect treatment efficacy, cotreatment compatibility and …

[PDF][PDF] 2-Chloroquinoline-3-carbaldehydes: synthesis, reactions and applications

BF Abdel-Wahab, RE Khidre, AA Farahat, AAS El-Ahl - Arkivoc, 2012 - academia.edu
This review summarizes the synthetic methods, reactions and biological applications of 2-
chloroquinoline-3-carbaldehydes during the period from 1999 to 2011. The reactions are …

Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus

JA Makawana, DC Mungra, MP Patel… - Bioorganic & medicinal …, 2011 - Elsevier
A new series of fused pyran derivatives 5a–x bearing 2-morpholinoquinoline nucleus has
been synthesized under microwave irradiation by a reaction of 2-morpholinoquinoline-3 …