The frontiers of bioimaging are currently being pushed toward the integration and correlation
of several modalities to tackle biomedical research questions holistically and across multiple …

Highlights•Currently a vast heterogeneity in synergistic drug action scoring and analysis
exists.•Novel cellular models offer robust ways to identify relevant combination …

Cell-line screens create expansive datasets for learning predictive markers of drug
response, but these models do not readily translate to the clinic with its diverse contexts and …

Drug combinations are of great interest for cancer treatment. Unfortunately, the discovery of
synergistic combinations by purely experimental means is only feasible on small sets of …

A growing number of failing clinical trials for cancer therapy are substantiating the need to
upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in …

Genetic alterations drive tumor onset and progression. However, the cross-talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Complex diseases like cancer are regulated by large, interconnected networks with many
pathways affecting cell proliferation, invasion, and drug resistance. However, current cancer …

This review explores the concept of synergy in pharmacology, emphasizing its importance in
optimizing treatment outcomes through the combination of drugs with different mechanisms …

Background Neurological and ophthalmological neurodegenerative diseases in large part
share underlying biology and pathophysiology. Despite extensive preclinical research on …

In an era of high-throughput “omic” technologies, the unprecedented amount of data that can
be generated presents a significant opportunity but simultaneously an even greater …