Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

Background Knowledge about and identification of T cell tumor antigens may inform the
development of T cell receptor-engineered adoptive cell transfer or personalized cancer …

The study of ankylosing spondylitis (AS) has made significant progress over the last decade.
Genome-wide association studies have identified and further substantiated the role of …

Four inflammatory diseases are strongly associated with Major Histocompatibility Complex
class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A* 29: 02), ankylosing …

Abstract Purpose of Review Ankylosing spondyloarthritis (AS) is a chronic inflammatory
disease that involves the axial joints and entheses. Extra-spinal manifestations such as …

To explore the contribution of functional coding variants to psoriasis, we analyzed
nonsynonymous single-nucleotide variants (SNVs) across the genome by exome …

Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in
trimming of peptides to an optimal length for presentation by major histocompatibility …