Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
Double-strand break repair: 53BP1 comes into focus
S Panier, SJ Boulton - Nature reviews Molecular cell biology, 2014 - nature.com
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …
DNA replication origin activation in space and time
M Fragkos, O Ganier, P Coulombe… - Nature reviews Molecular …, 2015 - nature.com
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
CTCF and cohesin in genome folding and transcriptional gene regulation
M Merkenschlager, EP Nora - Annual review of genomics and …, 2016 - annualreviews.org
Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
Shieldin–the protector of DNA ends
D Setiaputra, D Durocher - EMBO reports, 2019 - embopress.org
DNA double‐strand breaks are a threat to genome integrity and cell viability. The nucleolytic
processing of broken DNA ends plays a central role in dictating the repair processes that will …
processing of broken DNA ends plays a central role in dictating the repair processes that will …
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
JR Chapman, P Barral, JB Vannier, V Borel, M Steger… - Molecular cell, 2013 - cell.com
The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells
H Técher, S Koundrioukoff, A Nicolas… - Nature Reviews …, 2017 - nature.com
The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …
genome maintenance, and has a major impact on human diseases, notably, tumour …
53BP1 regulates DSB repair using Rif1 to control 5′ end resection
M Zimmermann, F Lottersberger, SB Buonomo, A Sfeir… - Science, 2013 - science.org
The choice between double-strand break (DSB) repair by either homology-directed repair
(HDR) or nonhomologous end joining (NHEJ) is tightly regulated. Defects in this regulation …
(HDR) or nonhomologous end joining (NHEJ) is tightly regulated. Defects in this regulation …
DNA replication timing
N Rhind, DM Gilbert - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …
structure, and genome evolution. Recent advances in genome-scale mapping of replication …
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
M Di Virgilio, E Callen, A Yamane, W Zhang… - Science, 2013 - science.org
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead
to the loss of genetic information and chromosome rearrangements. The DNA repair protein …
to the loss of genetic information and chromosome rearrangements. The DNA repair protein …