British Society of Gastroenterology position statement on serrated polyps in the colon and rectum
Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …
[HTML][HTML] TGFβ in cancer
J Massagué - Cell, 2008 - cell.com
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan
biology, and its misregulation can result in tumor development. The regulatory cytokine …
biology, and its misregulation can result in tumor development. The regulatory cytokine …
Diagnosis and management of cancer risk in the gastrointestinal hamartomatous polyposis syndromes: recommendations from the US Multi-Society Task Force on …
The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant
disorders associated with an increased risk of benign and malignant intestinal and …
disorders associated with an increased risk of benign and malignant intestinal and …
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
HT Lynch, PM Lynch, SJ Lanspa, CL Snyder… - Clinical …, 2009 - Wiley Online Library
More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
[HTML][HTML] Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients
Purpose The aim of this study was to determine the clinical and molecular characteristics of
2,079 patients who underwent hereditary cancer multigene panel testing. Methods Panels …
2,079 patients who underwent hereditary cancer multigene panel testing. Methods Panels …
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
EL Greer, PR Oskoui, MR Banko, JM Maniar… - Journal of Biological …, 2007 - ASBMB
The maintenance of homeostasis throughout an organism's life span requires constant
adaptation to changes in energy levels. The AMP-activated protein kinase (AMPK) plays a …
adaptation to changes in energy levels. The AMP-activated protein kinase (AMPK) plays a …
[HTML][HTML] Update on genetic predisposition to colorectal cancer and polyposis
The present article summarizes recent developments in the characterization of genetic
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …
[HTML][HTML] Role of transforming growth factor-β superfamily signaling pathways in human disease
KJ Gordon, GC Blobe - Biochimica et Biophysica Acta (BBA)-Molecular …, 2008 - Elsevier
Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …
essential regulators of cellular processes including proliferation, differentiation, migration …
S3-leitlinie–kolorektales karzinom
W Schmiegel, B Buchberger… - Zeitschrift für …, 2017 - thieme-connect.com
2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …
[HTML][HTML] Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis
J McDonald, P Bayrak-Toydemir, RE Pyeritz - Genetics in medicine, 2011 - Elsevier
Abstract Abstract Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) is
a disorder of development of the vasculature characterized by telangiectases and …
a disorder of development of the vasculature characterized by telangiectases and …