Beneficial effects of betaine: a comprehensive review
MK Arumugam, MC Paal, TM Donohue Jr, M Ganesan… - Biology, 2021 - mdpi.com
Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …
ingredients protect against the development of liver disease because they possess …
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease …
W Rungratanawanich, JW Ballway, X Wang… - Pharmacology & …, 2023 - Elsevier
Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …
influenced by environmental factors and metabolic changes to modulate gene activity with …
A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo
R Xiao, T Ran, Q Huang, G Hu… - Proceedings of the …, 2022 - National Acad Sciences
Jumonji C-domain-containing protein 6 (JMJD6), an iron (Fe2+) and α-ketoglutarate (α-KG)-
dependent oxygenase, is expressed at high levels, correlated with poor prognosis, and …
dependent oxygenase, is expressed at high levels, correlated with poor prognosis, and …
The small members of the JMJD protein family: Enzymatic jewels or jinxes?
S Oh, S Shin, R Janknecht - Biochimica et Biophysica Acta (BBA)-Reviews …, 2019 - Elsevier
Jumonji C domain-containing (JMJD) proteins are mostly epigenetic regulators that
demethylate histones. However, a hitherto neglected subfamily of JMJD proteins …
demethylate histones. However, a hitherto neglected subfamily of JMJD proteins …
Jumonji domain‐containing protein 6 protein and its role in cancer
J Yang, S Chen, Y Yang, X Ma, B Shao… - Cell …, 2020 - Wiley Online Library
The jumonji domain‐containing protein 6 (JMJD6) is a Fe (II)‐and 2‐oxoglutarate (2OG)‐
dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of …
dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of …
Alcohol metabolism potentiates HIV-induced hepatotoxicity: contribution to end-stage liver disease
In an era of improved survival due to modern antiretroviral therapy, liver disease has
become a major cause of morbidity and mortality, resulting in death in 15–17% of human …
become a major cause of morbidity and mortality, resulting in death in 15–17% of human …
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination
W Zhang, Q Wang, F Yang, Z Zhu, Y Duan… - PLoS …, 2021 - journals.plos.org
The negative regulation of antiviral immune responses is essential for the host to maintain
homeostasis. Jumonji domain-containing protein 6 (JMJD6) was previously identified with a …
homeostasis. Jumonji domain-containing protein 6 (JMJD6) was previously identified with a …
Hepatocyte PRMT1 protects from alcohol induced liver injury by modulating oxidative stress responses
J Zhao, A Adams, SA Weinman, I Tikhanovich - Scientific Reports, 2019 - nature.com
Abstract Protein Arginine methyltransferase 1 (PRMT1) is the main enzyme of cellular
arginine methylation. Previously we found that PRMT1 activity in the liver is altered after …
arginine methylation. Previously we found that PRMT1 activity in the liver is altered after …
Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes
Hepatitis B virus (HBV) infection and alcoholism are major public health problems
worldwide, contributing to the development of end-stage liver disease. Alcohol intake affects …
worldwide, contributing to the development of end-stage liver disease. Alcohol intake affects …
Second hits exacerbate alcohol-related organ damage: an update
Chronic and excessive alcohol abuse cause direct and indirect detrimental effects on a wide
range of body organs and systems and accounts for~ 4% of deaths worldwide. Many factors …
range of body organs and systems and accounts for~ 4% of deaths worldwide. Many factors …