Peptide-based subunit vaccines are of great interest in modern immunotherapy as they are
safe, easy to produce and well defined. However, peptide antigens produce a relatively …

Valvular heart diseases in Africa affect mainly children and young adults and are a result of
rheumatic fever. Rheumatic fever is a preventable disease, but in Africa the combination of a …

Bacteria represent the vast majority of biological diversity found on Earth. In this review, we
focus on selected aspects of their genetic material, those providing insight into structural …

Background It is proposed that the biggest gap in control of rheumatic heart disease is in
implementing of ineffective primary and secondary preventive measures. These measures …

Streptococcal toxic shock syndrome (STSS) caused by Streptococcus pyogenes is a clinical
condition with a high mortality rate despite modern intensive care. A key feature of STSS is …

Abstract Background Group A Streptococcus (GAS) strain diversity varies across different
regions of the world, according to low versus high-income countries. These differences may …

Background Binding of serum components by surface M-related proteins, encoded by the
emm genes, in streptococci constitutes a major virulence factor in this important group of …

Dengue, caused by the dengue virus (DENV), is a prevalent arthropod-borne disease in
humans and poses a significant burden on public health. Severe cases of dengue can be …

Background. The worldwide burden of the Group A Streptococcus (GAS) primary infection
and sequelae is considerable, although immunization programs with broad coverage of the …

Molecular mimicry between group A streptococcus and host antigens has important roles in
the development of post-streptococcal sequelae, including glomerulonephritis and …