The ability to regenerate amputated or injured tissues and organs is a fascinating property
shared by several invertebrates and, interestingly, some vertebrates. The mechanism of …

Gene-editing systems have emerged as bioengineering tools in recent years. Classical
gene-editing systems include zinc-finger nucleases (ZFNs), transcription activator-like …

Observations on the ontogeny and diversity of salamanders provided some of the earliest
evidence that shifts in developmental trajectories have made a substantial contribution to the …

Marsupials represent one of three extant mammalian subclasses with very unique
characteristics not shared by other mammals. Most notably, much of the development of …

Urodele newts have unique biological properties, notably including prominent regeneration
ability. The Iberian ribbed newt, Pleurodeles waltl, is a promising model amphibian …

Skin wounds are among the most common injuries in animals and humans. Vertebrate skin
is composed of an epidermis and dermis. After a deep skin injury in mammals, the wound …

Among tetrapods, only salamanders can regenerate their limbs and tails throughout life. This
amazing regenerative ability has attracted the attention of scientists for hundreds of years …

Background Previous studies have suggested that macrophages are present during lens
regeneration in newts, but their role in the process is yet to be elucidated. Methods Here we …

Severe muscle injury causes distress and difficulty in humans. Studying the high
regenerative ability of the axolotls may provide hints for the development of an effective …

In the last decade, the CRISPR/Cas9 bacterial virus defense system has been adapted as a
user-friendly, efficient, and precise method for targeted mutagenesis in eukaryotes. Though …