Extracellular matrix mechanobiology in cancer cell migration
The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube
AJ Crawford, A Forjaz, J Bons, I Bhorkar, T Roy… - Science …, 2024 - science.org
The fallopian tubes play key roles in processes from pregnancy to ovarian cancer where
three-dimensional (3D) cellular and extracellular interactions are important to their …
three-dimensional (3D) cellular and extracellular interactions are important to their …
Collagen fiber centerline tracking in fibrotic tissue via deep neural networks with variational autoencoder-based synthetic training data generation
The role of fibrillar collagen in the tissue microenvironment is critical in disease contexts
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal
dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor …
dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor …
Small extracellular vesicles promote stiffness-mediated metastasis
Tissue stiffness is a critical prognostic factor in breast cancer and is associated with
metastatic progression. Here we show an alternative and complementary hypothesis of …
metastatic progression. Here we show an alternative and complementary hypothesis of …
Targeting tumor extracellular matrix activates the tumor-draining lymph nodes
Disruption of the tumor extracellular matrix (ECM) may alter immune cell infiltration into the
tumor and antitumor T cell priming in the tumor-draining lymph nodes (tdLNs). Here, we …
tumor and antitumor T cell priming in the tumor-draining lymph nodes (tdLNs). Here, we …
A hybrid breast cancer classification algorithm based on meta-learning and artificial neural networks
L Han, Z Yin - Frontiers in Oncology, 2022 - frontiersin.org
The incidence of breast cancer in women has surpassed that of lung cancer as the world's
leading new cancer case. Regular screening and measures become an effective way to …
leading new cancer case. Regular screening and measures become an effective way to …
Precision-engineered biomimetics: the human fallopian tube
AJ Crawford, A Forjaz, I Bhorkar, T Roy, D Schell… - bioRxiv, 2023 - biorxiv.org
The fallopian tube has an essential role in several physiological and pathological processes
from pregnancy to ovarian cancer. However, there are no biologically relevant models to …
from pregnancy to ovarian cancer. However, there are no biologically relevant models to …
Elastic parameter identification of three-dimensional soft tissue based on deep neural network
Z Hu, S Liao, J Zhou, Q Chen, R Wu - Journal of the Mechanical Behavior of …, 2024 - Elsevier
In the field of virtual surgery and deformation simulation, the identification of elastic
parameters of human soft tissues is a critical technology that directly affects the accuracy of …
parameters of human soft tissues is a critical technology that directly affects the accuracy of …
Augmented data strategies for enhanced computer vision performance in breast cancer diagnosis
A Kaffashbashi, V Sobhani, F Goodarzian… - Journal of Ambient …, 2024 - Springer
Breast cancer remains a formidable global health challenge, exacting a heavy toll on
women's lives and necessitating advanced diagnostic methodologies. This study delves into …
women's lives and necessitating advanced diagnostic methodologies. This study delves into …