Obesity is one of the major risk factors for the development of both impaired glucose
tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide …

Microvascular complications in diabetes are associated with poor long-term diabetes control
as measured by HbA1c levels. Glucose fluctuations are related to oxidative stress …

Background Advanced glycation end-products (AGEs) are elevated under diabetic
conditions and associated with insulin resistance, endothelial dysfunction and vascular …

Abstract Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A, are widely used to
treat hypercholesterolemia. In addition, statins have been suggested to reduce the risk of …

Hyperuricemia, defined as elevated serum concentrations of uric acid (UA) above 416 µmol
L− 1, is related to the development of cardiometabolic disorders, probably via induction of …

Cardiovascular diseases (CVD) are a significant and growing burden on global health
services, and it is now accepted that impairment of vascular function represents a major …

Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms
that determine cellular sensitivity to inflammation are incompletely understood. Here, we …

Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the
underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole …

Hyperglycaemia, hypertension, dyslipidemia and insulin resistance collectively impact on
the myocardium of people with diabetes, triggering molecular, structural and myocardial …

Insulin resistance is characteristic of pregnancies where the mother shows metabolic
alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or …