The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …

The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …

Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …

Highlights•S. aureus produces a wide variety of toxins mostly aimed to evade elimination by
host defenses.•Many S. aureus toxins are encoded on mobile genetic elements, leading to a …

Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …

The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-
resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus …

Staphylococcus aureus is an important human pathogen and a leading cause of death
worldwide. Phenol-soluble modulins (PSMs) have recently emerged as a novel toxin family …

Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune
defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a …

Phenol-soluble modulins (PSMs) are a recently discovered family of amphipathic, alpha-
helical peptides that have multiple roles in staphylococcal pathogenesis and contribute to a …

Bacteria use dedicated mechanisms to respond adequately to fluctuating environments and
to optimize their chances of survival in harsh conditions. One of the major stress responses …