Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Co-culturing of cells in in vitro tissue models is widely used to study how they interact with
each other. These models serve to represent a variety of processes in the human body such …

Cellular models are needed to study human development and disease in vitro, and to
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …

Microplastic particles (MP) has been detected in the environment widespread. Human
beings are inevitably exposed to MP via multiple routines. However, the hazard …

Human organoid systems recapitulate in vivo organ architecture yet fail to capture complex
pathologies such as inflammation and fibrosis. Here, using 11 different healthy and …

Background & Aims The development of hepatic models capable of long-term expansion
with competent liver functionality is technically challenging in a personalized setting. Stem …

The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …

The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

The pathogenesis of idiopathic pulmonary fibrosis (IPF), an intractable interstitial lung
disease, is unclear. Recessive mutations in some genes implicated in Hermansky-Pudlak …