Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …

Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic
activity toward a plethora of clinically important medications. Thus, single nucleotide variants …

Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …

The cytochrome P450, family 2, subfamily C, polypeptide 19 (CYP2C19) gene is located
within a cluster of cytochrome P450 genes (centromere-CYP2C18-CYP2C19-CYP2C9 …

The majority of drugs are metabolized by cytochrome P450 (CYP) enzymes, primarily
belonging to the CYP1, CYP2 and CYP3 families. Genetic variations are the main cause of …

A number of mutations in GATA4 and NKX2. 5 have been identified to be causative for a
subset of familial congenital heart defects (CHDs) and a small number of sporadic CHDs. In …

Abstract Cytochrome P450 2C19 (CYP2C19) is involved in the metabolism of many drugs.
Extensive studies have demonstrated that genetic variants and endogenous and …

Background TBX1 (T-box transcription factor 1) is a major candidate gene that likely
contributes to the etiology of velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS) …

Aims: This study was aimed at elucidating the common sequence variation present in the
CYP2C19 gene within the South African Xhosa population and comparing it with the Cape …

Retinoic acid receptors (RARs), retinoid X receptors (RXRs) and thyroid hormone receptors
(TRs) are nuclear receptors that are crucial transcriptional regulators of many cellular …