Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis
There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …
progression and metastasis phases. In many cases, the molecular mechanisms …
Melatonin—A pleiotropic, orchestrating regulator molecule
R Hardeland, DP Cardinali, V Srinivasan… - Progress in …, 2011 - Elsevier
Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …
Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
Melatonin: an inhibitor of breast cancer
SM Hill, VP Belancio, RT Dauchy… - Endocrine-related …, 2015 - erc.bioscientifica.com
The present review discusses recent work on melatonin-mediated circadian regulation, the
metabolic and molecular signaling mechanisms that are involved in human breast cancer …
metabolic and molecular signaling mechanisms that are involved in human breast cancer …
Circadian organization of the mammalian retina: from gene regulation to physiology and diseases
The retinal circadian system represents a unique structure. It contains a complete circadian
system and thus the retina represents an ideal model to study fundamental questions of how …
system and thus the retina represents an ideal model to study fundamental questions of how …
Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction
R Hardeland - The Scientific World Journal, 2012 - Wiley Online Library
Melatonin is a highly pleiotropic signaling molecule, which is released as a hormone of the
pineal gland predominantly during night. Melatonin secretion decreases during aging …
pineal gland predominantly during night. Melatonin secretion decreases during aging …
Melatonin: an underappreciated player in retinal physiology and pathophysiology
In the vertebrate retina, melatonin is synthesized by the photoreceptors with high levels of
melatonin at night and lower levels during the day. Melatonin exerts its influence by …
melatonin at night and lower levels during the day. Melatonin exerts its influence by …
Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose
E Mühlbauer, E Gross, K Labucay, S Wolgast… - European journal of …, 2009 - Elsevier
The transmission of circadian rhythms is mediated by specific promoter sequences binding a
particular circadian clock factor. The pineal hormone melatonin acts via G-protein-coupled …
particular circadian clock factor. The pineal hormone melatonin acts via G-protein-coupled …
Ubiquitous light-emitting diodes: potential threats to retinal circadian rhythms and refractive development
C Zhang, Z Zhu, J Zhao, Y Li, Z Zhang… - Science of The Total …, 2023 - Elsevier
The use of light-emitting diodes (LEDs) has increased considerably in the 21st century with
humans living in a modern photoperiod with brighter nights and dimmer days. Prolonged …
humans living in a modern photoperiod with brighter nights and dimmer days. Prolonged …
Evidence that membrane‐bound G protein‐coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral …
Melatonin is synthesized and released by the pineal gland in a circadian rhythm, and many
of its peripheral actions are mediated via membrane MT1 and MT2 receptors. Apart from its …
of its peripheral actions are mediated via membrane MT1 and MT2 receptors. Apart from its …