Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

Myelinated nerve fibers have evolved to enable fast and efficient transduction of electrical
signals in the nervous system. To act as an electric insulator, the myelin sheath is formed as …

Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is
unknown how glucose utilization and glycolysis are adapted to the different axonal energy …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Oligodendrocytes are glial cells that populate the entire CNS after they have differentiated
from oligodendrocyte progenitor cells. From birth onward, oligodendrocytes initiate wrapping …

Oligodendroglia support axon survival and function through mechanisms independent of
myelination, and their dysfunction leads to axon degeneration in several diseases. The …

Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …

Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-
term axonal integrity,,. However, the underlying support mechanisms are not understood …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …