G-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …
particular nucleic acid structure was discussed to play a role in malignant transformation and …
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
Non-canonical DNA structures: Diversity and disease association
A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
The i-motif as a molecular target: more than a complementary DNA secondary structure
SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
[HTML][HTML] Major achievements in the design of quadruplex-interactive small molecules
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …
acids have great potential as selective drugs or as tools in drug target discovery programs …
Decoding complexity in biomolecular recognition of DNA i-motifs with microarrays
DNA i-motifs (iMs) are non-canonical C-rich secondary structures implicated in numerous
cellular processes. Though iMs exist throughout the genome, our understanding of iM …
cellular processes. Though iMs exist throughout the genome, our understanding of iM …
Quadruplex ligands in cancer therapy
V Sanchez-Martin, M Soriano, JA Garcia-Salcedo - Cancers, 2021 - mdpi.com
Simple Summary Four-stranded nucleic acid secondary structures (quadruplexes) including
DNA G-quadruplexes, RNA G-quadruplexes and i-Motifs display key regulatory functions in …
DNA G-quadruplexes, RNA G-quadruplexes and i-Motifs display key regulatory functions in …
A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA
E Cadoni, L De Paepe, G Colpaert, R Tack… - Nucleic Acids …, 2023 - academic.oup.com
The importance of non-canonical DNA structures such as G-quadruplexes (G4) and
intercalating-motifs (iMs) in the fine regulation of a variety of cellular processes has been …
intercalating-motifs (iMs) in the fine regulation of a variety of cellular processes has been …
Chemical regulation of DNA i‐motifs for nanobiotechnology and therapeutics
DNA sequences rich in cytosine have the propensity, under acidic pH, to fold into four‐
stranded intercalated DNA structures called i‐motifs. Recent studies have provided …
stranded intercalated DNA structures called i‐motifs. Recent studies have provided …