Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Decades ago, mitogen-promoted signaling duration and strength were observed to be
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …

The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This
complex, acellular entity is composed of hundreds of individual molecules whose assembly …

Cell death events continuously challenge epithelial barrier function yet are crucial to
eliminate old or critically damaged cells. How such apoptotic events are spatio-temporally …

YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How
cells ensure the selective activation of YAP effector genes is unknown. This knowledge is …

Cell signaling networks coordinate specific patterns of protein expression in response to
external cues, yet the logic by which signaling pathway activity determines the eventual …

Kinase translocation reporters (KTRs) are genetically encoded fluorescent activity sensors
that convert kinase activity into a nucleocytoplasmic shuttling equilibrium for visualizing …

The Rhizoclosmatium globosum genome encodes three rhodopsin-guanylyl cyclases
(RGCs), which are predicted to facilitate visual orientation of the fungal zoospores. Here, we …

Signaling proteins display remarkable cell-to-cell heterogeneity in their dynamic responses
to stimuli, but the consequences of this heterogeneity remain largely unknown. For instance …