The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Mechanosensation is the ability to detect dynamic mechanical stimuli (eg, pressure, stretch,
and shear stress) and is essential for a wide variety of processes, including our sense of …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

Eating and drinking generate sequential mechanosensory signals along the digestive tract.
These signals are communicated to the brain for the timely initiation and regulation of …

Nearly all structures in our body experience mechanical forces. At a molecular scale, these
forces are detected by ion channels that function as mechanotransducers converting …

A variety of mechanosensory neurons are involved in touch, proprioception, and pain. Many
molecular components of the mechanotransduction machinery subserving these sensory …

Single-cell RNA-sequencing and in vivo functional imaging provide expansive but
disconnected views of neuronal diversity. Here, we developed a strategy for linking these …

Single-cell RNA sequencing (scRNA-seq) has allowed profiling cell types of the dorsal root
ganglia (DRG) and their transcriptional states in physiology and chronic pain. However, the …

The central mechanisms underlying pain chronicity remain elusive. Here, we identify a
reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the …