Advances in the automation of whole-cell patch clamp technology
Electrophysiology is the study of neural activity in the form of local field potentials, current
flow through ion channels, calcium spikes, back propagating action potentials and somatic …
flow through ion channels, calcium spikes, back propagating action potentials and somatic …
Progress in automating patch clamp cellular physiology
LA Annecchino, SR Schultz - Brain and neuroscience …, 2018 - journals.sagepub.com
Patch clamp electrophysiology has transformed research in the life sciences over the last
few decades. Since their inception, automatic patch clamp platforms have evolved …
few decades. Since their inception, automatic patch clamp platforms have evolved …
High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp
Y Peng, FX Mittermaier, H Planert, UC Schneider… - Elife, 2019 - elifesciences.org
Comparing neuronal microcircuits across different brain regions, species and individuals
can reveal common and divergent principles of network computation. Simultaneous patch …
can reveal common and divergent principles of network computation. Simultaneous patch …
[HTML][HTML] Closed-loop real-time imaging enables fully automated cell-targeted patch-clamp neural recording in vivo
Targeted patch-clamp recording is a powerful method for characterizing visually identified
cells in intact neural circuits, but it requires skill to perform. We previously developed an …
cells in intact neural circuits, but it requires skill to perform. We previously developed an …
[HTML][HTML] Automatic deep learning-driven label-free image-guided patch clamp system
Patch clamp recording of neurons is a labor-intensive and time-consuming procedure. Here,
we demonstrate a tool that fully automatically performs electrophysiological recordings in …
we demonstrate a tool that fully automatically performs electrophysiological recordings in …
In Vivo Glutamate Sensing inside the Mouse Brain with Perovskite Nickelate–Nafion Heterostructures
Y Sun, TNH Nguyen, A Anderson… - … applied materials & …, 2020 - ACS Publications
Glutamate, one of the main neurotransmitters in the brain, plays a critical role in
communication between neurons, neuronal development, and various neurological …
communication between neurons, neuronal development, and various neurological …
Visual experience-dependent oscillations and underlying circuit connectivity changes are impaired in Fmr1 KO mice
Fragile X syndrome (FX), the most common inherited form of autism and intellectual
disability, is a condition associated with visual perceptual learning deficits. We recently …
disability, is a condition associated with visual perceptual learning deficits. We recently …
Visual familiarity induced 5-Hz oscillations and improved orientation and direction selectivities in V1
M Gao, S Lim, AA Chubykin - Journal of Neuroscience, 2021 - Soc Neuroscience
Neural oscillations play critical roles in information processing, communication between
brain areas, learning, and memory. We have recently discovered that familiar visual stimuli …
brain areas, learning, and memory. We have recently discovered that familiar visual stimuli …
PatcherBot: a single-cell electrophysiology robot for adherent cells and brain slices
Objective. Intracellular patch-clamp electrophysiology, one of the most ubiquitous, high-
fidelity techniques in biophysics, remains laborious and low-throughput. While previous …
fidelity techniques in biophysics, remains laborious and low-throughput. While previous …
Deep learning-based real-time detection of neurons in brain slices for in vitro physiology
A common electrophysiology technique used in neuroscience is patch clamp: a method in
which a glass pipette electrode facilitates single cell electrical recordings from neurons …
which a glass pipette electrode facilitates single cell electrical recordings from neurons …