[HTML][HTML] Placental malaria: a new insight into the pathophysiology

L Sharma, G Shukla - Frontiers in medicine, 2017 - frontiersin.org
Malaria in pregnancy poses a great health risk to mother and her fetus and results into
complications, such as abortion, still birth, intra uterine growth retardation, and low birth …

[HTML][HTML] Designing a VAR2CSA-based vaccine to prevent placental malaria

M Fried, PE Duffy - Vaccine, 2015 - Elsevier
Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

A Srivastava, S Gangnard, A Round… - Proceedings of the …, 2010 - National Acad Sciences
Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …

[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

[HTML][HTML] Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

[HTML][HTML] The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains

M Dahlbäck, LM Jørgensen, MA Nielsen… - Journal of Biological …, 2011 - ASBMB
Malaria during pregnancy is a major health problem for African women. The disease is
caused by Plasmodium falciparum malaria parasites, which accumulate in the placenta by …

[HTML][HTML] Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

K Singh, AG Gittis, P Nguyen, DC Gowda… - Nature structural & …, 2008 - nature.com
Plasmodium falciparum–infected erythrocytes bind to chondroitin sulfate A (CSA) in the
placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane …

[HTML][HTML] Var2CSA minimal CSA binding region is located within the N-terminal region

A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …

The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development

L Hviid - Human vaccines, 2010 - Taylor & Francis
There is substantial immuno-epidemiological evidence that the parasite-encoded, so-called
variant surface antigens (VSAs) such as PfEMP1 on the surface of infected erythrocytes (IEs) …

[HTML][HTML] Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum

A Ghumra, P Khunrae, R Ataide, A Raza, SJ Rogerson… - PloS one, 2011 - journals.plos.org
Background Rosetting is a Plasmodium falciparum virulence factor implicated in the
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …